Curriculum Vitae

Dr. Heba Mohamed Elbedaiwy

Associate Professor of Pharmaceutics

Faculty of Pharmacy – Damanhour University

Personal:

Qualification degrees:

• B.Sc.in pharmaceutical sciences, Faculty of pharmacy, Tanta University, Egypt, 1999.
• M.Sc.degree in pharmaceutical sciences (BIOPHARMACEUTICS), Faculty of pharmacy, Tanta University, Egypt, 2008.

Title thesis: "Studies to enhance the intestinal absorption and bioavailablity of acyclovir"

• Ph.D.degree in pharmaceutical sciences (BIOPHARMACEUTICS), Faculty of pharmacy, Tanta University, Egypt, 2012.

Title thesis: "A study to investigate the effect of liquisolid technique on the dissoliution characteristics of a model class II drug"

PositionOccupied

Brief description of duties:

Teaching Courses in Faculty of Pharmacy, Damanhour University, Damanhour, Egypt:

1. Physical Pharmacy (1^st year students – Pharm D program- Damanhour University).
2. Physical Pharmacy (1^st year students – Pharm D clinical program- Damanhour University).
3. Pharmacy orientation (1^st year students – Pharm D program- Damanhour University).
4. Pharmacy orientation (1^st year students – Pharm D clinical program- Damanhour University).
5. Pharmacy legislation (2^ndyear students – Pharm D program- Damanhour University).
6. Pharmacy legislation (2^nd year students – Pharm D clinical program- Damanhour University).
7. Pharmaceutical Dosage Form III (3^rd year students - Pharm D clinical program- Damanhour University).
8. Pharmaceutics III (3^rd year students - Pharm D program- Damanhour University).
9. Biopharmaceutics and Pharmacokinetics (3rd year students -Clinical Pharmacy Program - Damanhour University)
10. Biopharmaceutics, Pharmacokinetics, and drug stability (3rd year students- New Program - Damanhour University).
11. Drug Delivery System & Targeting (4^th year students- New Program -Damanhour University).
12. Controlled drug delivery (4 ^th Clinical Pharmacy Program -Damanhour University).
13. cosmetics (4^th year students- New Program -Damanhour University).
14. Pharmaceutics IV (4 ^th year students- old Program -Damanhour University).
15. Industrial pharmacy (4 ^th year students- old Program – and new program -Damanhour University)
16. Pharmaceutics and Pharmacokinetics(Postgraduate students – master program)
17. Advanced drug delivery system (Postgraduate students – master program)
18. Advanced drug delivery (Postgraduate students – Doctorial program)
19. Drug targeting within the gastrointestinal tract ((Postgraduate students – Doctorial program)

Workshops and Courses:

Courses and workshops held in the Faculty and Leadership Development Project (FLDP), Egypt:

• Quality standards in the education process, June 2014.
• International publishing of scientific research, June 2014.
• Skills of electronic educations, August 2018.
• Conferences organization November 2020.
• Proposal of competition s initiatives for research February 2021.
• Exams and students evaluations systems December 2020.

Academic activities:

• Collaborated in preparing and establishing the bylaws of Pharmaceutics Department (Bachelor Degree of Pharmaceutical Sciences).
• Designed the courses of Pharmaceutics Department and its specifications (Master Degree  of Pharmaceutics).
• Designed the courses of Pharmaceutics Department and its specifications (Ph.D Degree  of Pharmaceutics).
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Community Involvement / Administrative Activity:

• Coordinator pf pharmaceutics department from 2015-2020.
• As a member of the Committee of Community Service and Environmental
  Development, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt (Academic year 2012-2013 - & 2014-2015).
• As a member of the Educational and students Committee, Faculty of Pharmacy, Damanhour University,(Academic years 2015-2020)and from (2022 until now)
• As a member of the Post Graduate Committee, Faculty of Pharmacy, Damanhour University,(Academic years 2020-2021)
• Participation in Summer Training Courses for the Third grade students, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.

Practical and Research Experience

Human studies:

• Bioequivalence study design, data collection, and data analysis.
• Evaluation of pharmacokinetic drug-drug interactions.
• Clinical experience in drug concentration monitoring and adjusting drug doses according to patient metabolic patterns and pharmacokinetic principles. Activities included demonstrating factors affecting patient drug blood levels and applying TDM as an integral part of drug therapy.
• Investigation of oral absorption of drugs in vivo.
• Making in vivo- in vitro correlation for many drugs.

Animal studies:

• Investigation of the regional differences in the absorption of the some drugs using in situ intestinal perfusion technique.
• Enhancement of oral absorption of drugs.
• Investigation of the effect of different formulations on some organs.

Analytical techniques:

HPLC (UV& Fluorescence) and UV spectroscopy.

Computer packages:

Pharmacokinetic data analysis with WinNonlin.

Statistical packages such as Minitab and SPSS.

Publications:

1. SA Helmy, Heba M El-Bedaiwy. A new and simple HPLC method for determination of etamsylate in human plasma and its application to pharmacokinetic study in healthy adult male volunteers. Saudi Pharmaceutical Journal 21 (4), 405-410
2. SA Helmy, Heba M El-Bedaiwy. Validation of a liquid chromatography method for the simultaneous determination of several nonsteroidal anti-inflammatory drugs in human plasma for therapeutic drug monitoring. Therapeutic drug monitoring 36 (1), 100-107
3. SA Helmy, Heba M El-Bedaiwy. HPLC determination of fexofenadine in human plasma for therapeutic drug monitoring and pharmacokinetic studies. Biomedical Chromatography 30 (7), 1059-1064
4. SA Helmy, Heba M El-Bedaiwy. In vitro dissolution similarity as a surrogate for in vivo bioavailability and therapeutic equivalence. Dissolution Technologies 23 (3), 32-39
5. Fatma A.Aboali,Doaa A.Habib,Heba M El-Bedaiwy,Ragwa M.Farid. Curcumin-loaded proniosomal gel as a biofreindly alternative for treatment of ocular inflammation: In-vitro and in-vivo assessment. International Journal of Pharmaceutics (2020)
6. SA Helmy, Heba M El-Bedaiwy. Simultaneous determination of paracetamol and methocarbamol in human plasma by HPLC using UV detection with time programming: Application to pharmacokinetic study. Drug research 64 (07), 363-367
7. SA Helmy, Heba M El-Bedaiwy. Effect of the formulation on the bioequivalence of meloxicam: tablet and suspension. Drug research 63 (07), 331-337
8. SA Helmy, Heba M El-Bedaiwy. Pharmacokinetics and comparative bioavailability of domperidone suspension and tablet formulations in healthy adult subjects. Clinical Pharmacology in Drug Development 3 (2), 126-131
9. SA Helmy, Heba M El-Bedaiwy. Piroxicam immediate release formulations: A fasting randomized open‐label crossover bioequivalence study in healthy volunteers. Clinical Pharmacology in Drug Development 3 (6), 466-471
10. SA Helmy, Heba M El-Bedaiwy. Pharmacokinetics and comparative bioavailability of allopurinol formulations in healthy subjects. Clinical Pharmacology in Drug Development 3 (5), 353-357

SA Helmy, Heba M El-Bedaiwy. Comparative in vitro dissolution and in vivo bioavailability of diflunisal/naproxen fixed-dose combination tablets and concomitant administration of diflunisal and naproxen in healthyadult subjects. Drug research 34 (03), 150-158

SA Helmy, Heba M El-Bedaiwy, SM El-Masry. Applying Biopharmaceutical Classification System criteria to predict the potential effect of Cremophor® RH 40 on fexofenadine bioavailability at higher doses. Therapeutic Delivery 11 (7), 447-464

1. SA Helmy, Heba M El-Bedaiwy, SM El-Masry. Effect of pineapple juice on the pharmacokinetics of celecoxib and montelukast in humans. Therapeutic Delivery 11 (5), 301-311
2. SA Helmy, Heba M El-Bedaiwy, NO Mansour. Dose Linearity of Glimepiride in Healthy Human Egyptian Volunteers. Clinical Pharmacology in Drug Development 2 (3), 264-269
3. Soha M El-Masry , Heba M El-Bedaiwy ,  Doaa A. Habib. Gastroretentive floating matrix of Cefditoren Pivoxil: 2³ full factorial design, Formulation, In-vitro evaluation and optimization. Journal of Applied Pharmaceutical Science 12 (02), 116-125
4. Soha M. El-masry, Heba M. ElBedaiwy, Mohammad M. Abd-Alhaseeb, Mohamed S. Abdel-Maksoud & Doaa A. Habib. Green polymer altered in-situ gel oral liquid sustainable release preparation of vildagliptin suitable for dysphagic diabetic patients: assessment in-vitro & in-vivo. Pharmaceutical development and technology28 (7), 585–594.
5. Amira E. El-Nahas, Heba M. Elbedaiwy, Maged W. Helmy, Amal H. El-Kamel. Simultaneous Estimation of Berberine and Piperine in a Novel Nanoformulation for Epilepsy Control via HPLC. Journal of Chromatographic Science, 00, 1–
6. Amira E. El-Nahas, Heba M. Elbedaiwy , Inas M. Masoud, Rania G. Aly, Maged W. Helmy, Amal H. El-Kamel. Berberine-loaded zein/hyaluronic acid composite nanoparticles for efficient brain uptake to alleviate neuro-degeneration in the pilocarpine model of epilepsy . European Journal of Pharmaceutics and Biopharmaceutics (188), 182-200.